Matthew 12: 46 - 50 Jesus' Mother and Brothers want to see Him

Mat 12:46  But while He yet talked with the people, behold, His mother and His brothers stood outside, desiring to speak with Him. 
Mat 12:47  Then one said to Him, Behold, Your mother and Your brothers stand outside, desiring to speak with You. 
Mat 12:48  And He answered and said to him who told Him, Who is My mother? And who are My brothers? 
Mat 12:49  And He stretched out His hand toward His disciples and said, Behold, My mother and My brothers! 
Mat 12:50  For whoever shall do the will of My Father in Heaven, the same is My brother and sister and mother. 
Introduction.
This is a very poignant section of Scripture where His Mother, Mary and His Brothers were standing outside wanting to speak with Him. Those who think that Mary was a Perpetual Virgin say that this could not have been his natural brothers. If you believe the Bible as it is written and don't attempt to add to it your own doctrines and interpretations then this was really His Mother and His Brothers.

Mat 12:46  But while He yet talked with the people, behold, His mother and His brothers stood outside, desiring to speak with Him. 
Notes
His mother and brethren stood without, desiring to speak with him, when they should have been standing within, desiring to hear him. They had the advantage of his daily converse in private, and therefore were less mindful to attend upon his public preaching. 

Note, Frequently those who are nearest to the means of knowledge and grace, are most negligent. Familiarity and easiness of access breed some degree of contempt. We are apt to neglect that this day, which we think we may have any day, forgetting that it is only the present time we can be sure of; tomorrow is none of ours. There is too much truth in that common proverb, “The nearer the church, the further from God;” it is pity it should be so. Matthew Henry
Cp Mat_13:55  Is not this the carpenter's son? Is not his mother called Mary? And his brothers, James and Joses and Simon and Judas, 
And Luk_8:19  And His mother and His brothers came to Him. And they could not come near Him because of the crowd. 

Mat 12:47  Then one said to Him, Behold, Your mother and Your brothers stand outside, desiring to speak with You.
Notes 
Absorbed in the awful warnings He was pouring forth, He felt this to be an unseasonable interruption, fitted to dissipate the impression made upon the large audience - such an interruption as duty to the nearest relatives did not require Him to give way to. But instead of a direct rebuke, He seizes on the incident to convey a sublime lesson, expressed in a style of inimitable condescension.


Mat 12:48  And He answered and said to him who told Him, Who is My mother? And who are My brothers? 
Notes
Who are those who are related to me? It seems as if Joseph had already passed away so His Mother and Four Brothers were there asking for Him. Actually because of the Crowds they thought that He was overdoing it as He had so many hanging on His Words and others waiting to be healed.

Who is my mother? ... - There was no want of affection or respect in Jesus toward his mother, as is proved by his whole life.See especially Luk_2:51, and Joh_19:25-27. 
Luk 2:51  And He went with them and came to Nazareth, and He was subject to them. But His mother kept all these sayings in her heart. 
Luk 2:52  And Jesus increased in wisdom and stature, and in favor with God and man. 

Joh 19:25  And His mother stood by the cross of Jesus, and His mother's sister, Mary the wife of Clopas, and Mary Magdalene. 
Joh 19:26  Then when Jesus saw His mother and the disciple whom He loved standing by, He said to His mother, Woman, behold your son! 
Joh 19:27  Then He said to the disciple, Behold your mother! And from that hour that disciple took her into his own home. 
This question was asked merely to “fix the attention” of the hearers and to prepare them for the answer - that is, to show them who sustained toward him the nearest and most tender relation. To do this he pointed to his disciples. Dear and tender as were the ties which bound him to his mother and brethren, yet those which bound him to his disciples were more tender and sacred. How great was his love for his disciples, when it was more than even that for his mother! And what a bright illustration of his own doctrine, that we ought to forsake father, and mother and friends, and houses, and lands, to be his followers!

Mat 12:49  And He stretched out His hand toward His disciples and said, Behold, My mother and My brothers! 

Mat 12:50  For whoever shall do the will of My Father in Heaven, the same is My brother and sister and mother. 
Notes
For whosoever shall do the will of my Father,.... This is not to be understood of a perfect obedience to the will of God, revealed in his righteous law; for since this cannot be performed by any mere man, no one could be in such a spiritual relation to Christ: but of the obedience of faith to the will of God, revealed in the Gospel; which is to believe in Christ, and have everlasting life; see Joh_6:40. This is the will of Christ's Father, 

which is in heaven, and which is good news from heaven, to sinners on earth; and which Christ came down from heaven to do, and to declare to the children of men: such as "hear the word of God and do it", as Luke says, Luk_8:21 that is, hear the Gospel, understand and believe it, and become obedient to the faith of it; these are in this near manner related to Christ, evidentially and openly, as well as those who were now present: 

the same is my brother, and sister, and mother; as dear to me, as such are to those, to whom they stood thus related in the flesh: and these natural relations serve to convey some ideas of that relation, union, nearness, and communion, there are between Christ and his people; all these relative characters may be observed in the book of Solomon's Song, to which our Lord may be reasonably thought to have respect; see Son_3:11.